Exercise in Individuals With CKD

Management of symptomatic carotid stenosis in individuals with CKD.

Evidence for anti-inflammatory effects of exercise in CKD.

CKD is associated with a complex state of immune dysfunction characterized by immune depression, predisposing patients to infections, and immune activation, resulting in inflammation that associates with higher risk of cardiovascular disease. Physical exercise may enhance immune function and exert anti-inflammatory effects, but such effects are unclear in CKD. We investigated the separate effec...

Shades of grey: the conundrum of implantable defibrillators in individuals with advanced CKD.

CKD contributes significantly to the global health burden, with a prevalence estimated at 10%–12% of individuals worldwide (1). Morbidity and mortality rates remain high in these individuals (2–5), and they are at a particularly magnified risk of sudden cardiac death (SCD) (6,7). To wit, in a study by Pun et al. (6) of 19,440 patients with coronary artery disease undergoing cardiac catheterizat...

APOL1 risk alleles among individuals with CKD in Northern Tanzania: A pilot study

INTRODUCTION In sub-Saharan Africa, approximately 100 million people have CKD, yet genetic risk factors are not well-understood. Despite the potential importance of understanding APOL1 risk allele status among individuals with CKD, little genetic research has been conducted. Therefore, we conducted a pilot study evaluating the feasibility of and willingness to participate in genetic research on...

Metabolic subtypes and risk of mortality in normal weight, overweight, and obese individuals with CKD.

BACKGROUND AND OBJECTIVES Higher body mass index (BMI) is paradoxically associated with lower mortality in persons with CKD, but whether cardiometabolic abnormalities modulate this association is unclear. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Participants with CKD from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study (n=4374) were analyzed. The harmonized cr...